AustralieFrV1, Main, Exploration, bibRecord, 000C20

Final analysis of survival outcomes in the randomized phase 3 FIRST trial.

Identifieur interne : 000C20 ( Main/Exploration ); précédent : 000C19; suivant : 000C21

Final analysis of survival outcomes in the randomized phase 3 FIRST trial.

Auteurs : Thierry Facon [France] ; Meletios A. Dimopoulos [Grèce] ; Angela Dispenzieri [États-Unis] ; John V. Catalano [Australie] ; Andrew Belch [Canada] ; Michele Cavo [Italie] ; Antonello Pinto [Italie] ; Katja Weisel [Allemagne] ; Heinz Ludwig [Autriche] ; Nizar J. Bahlis [Canada] ; Anne Banos [France] ; Mourad Tiab [France] ; Michel Delforge [Belgique] ; Jamie D. Cavenagh [Royaume-Uni] ; Catarina Geraldes [Portugal] ; Je-Jung Lee ; Christine Chen [Canada] ; Albert Oriol [Espagne] ; Javier De La Rubia [Espagne] ; Darell White [Canada] ; Daniel Binder [Suisse] ; Jin Lu [République populaire de Chine] ; Kenneth C. Anderson [États-Unis] ; Philippe Moreau [France] ; Michel Attal [France] ; Aurore Perrot [France] ; Bertrand Arnulf [France] ; Lugui Qiu [République populaire de Chine] ; Murielle Roussel [France] ; Eileen Boyle [France] ; Salomon Manier [France] ; Mohamad Mohty [France] ; Herve Avet-Loiseau [France] ; Xavier Leleu [France] ; Annette Ervin-Haynes [États-Unis] ; Guang Chen [États-Unis] ; Vanessa Houck [États-Unis] ; Lotfi Benboubker [France] ; Cyrille Hulin [France]

Source :

Blood [ 1528-0020 ] ; 2017.

RBID : pubmed:29150421

Abstract

This FIRST trial final analysis examined survival outcomes in patients with transplant-ineligible newly diagnosed multiple myeloma (NDMM) treated with lenalidomide and low-dose dexamethasone until disease progression (Rd continuous), Rd for 72 weeks (18 cycles; Rd18), or melphalan, prednisone, and thalidomide (MPT; 72 weeks). The primary endpoint was progression-free survival (PFS; primary comparison: Rd continuous vs MPT). Overall survival (OS) was a key secondary endpoint (final analysis prespecified ≥ 60 months' follow-up). Patients were randomized to Rd continuous (n = 535), Rd18 (n = 541), or MPT (n = 547). At a median follow-up of 67 months, PFS was significantly longer with Rd continuous vs MPT (HR, 0.69; 96% CI, 0.59-0.79; P < .00001) and was similarly extended vs Rd18. Median OS was 10 months longer with Rd continuous vs MPT (59.1 vs 49.1 months; HR, 0.78; 95% CI, 0.63-0.95; P = .0144), and similar with Rd18 (62.3 months). In patients achieving complete or very good partial responses, Rd continuous had a ≈ 30-month-longer median time to next treatment vs Rd18 (69.5 vs 39.9 months). Over half of all patients who received second-line treatment were given a bortezomib-based therapy. Second-line outcomes were improved in patients receiving bortezomib after Rd continuous and Rd18 vs after MPT. No new safety concerns, including risk for secondary malignancies, were observed. Treatment with Rd continuous significantly improved survival outcomes vs MPT, supporting Rd continuous as a standard of care for patients with transplant-ineligible NDMM. Study registration is at Clinicaltrials.gov (NCT00689936) and EudraCT (2007-004823-39).

DOI: 10.1182/blood-2017-07-795047
PubMed: 29150421

Affiliations:

Le document en format XML

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<author><name sortKey="Lee, Je Jung" sort="Lee, Je Jung" uniqKey="Lee J" first="Je-Jung" last="Lee">Je-Jung Lee</name>
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<author><name sortKey="Chen, Christine" sort="Chen, Christine" uniqKey="Chen C" first="Christine" last="Chen">Christine Chen</name>
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<author><name sortKey="De La Rubia, Javier" sort="De La Rubia, Javier" uniqKey="De La Rubia J" first="Javier" last="De La Rubia">Javier De La Rubia</name>
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<author><name sortKey="Binder, Daniel" sort="Binder, Daniel" uniqKey="Binder D" first="Daniel" last="Binder">Daniel Binder</name>
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<author><name sortKey="Lu, Jin" sort="Lu, Jin" uniqKey="Lu J" first="Jin" last="Lu">Jin Lu</name>
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<author><name sortKey="Moreau, Philippe" sort="Moreau, Philippe" uniqKey="Moreau P" first="Philippe" last="Moreau">Philippe Moreau</name>
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<author><name sortKey="Attal, Michel" sort="Attal, Michel" uniqKey="Attal M" first="Michel" last="Attal">Michel Attal</name>
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<author><name sortKey="Perrot, Aurore" sort="Perrot, Aurore" uniqKey="Perrot A" first="Aurore" last="Perrot">Aurore Perrot</name>
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<orgName type="university">Université de Lorraine</orgName>
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<author><name sortKey="Arnulf, Bertrand" sort="Arnulf, Bertrand" uniqKey="Arnulf B" first="Bertrand" last="Arnulf">Bertrand Arnulf</name>
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<author><name sortKey="Qiu, Lugui" sort="Qiu, Lugui" uniqKey="Qiu L" first="Lugui" last="Qiu">Lugui Qiu</name>
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<author><name sortKey="Roussel, Murielle" sort="Roussel, Murielle" uniqKey="Roussel M" first="Murielle" last="Roussel">Murielle Roussel</name>
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<author><name sortKey="Boyle, Eileen" sort="Boyle, Eileen" uniqKey="Boyle E" first="Eileen" last="Boyle">Eileen Boyle</name>
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<author><name sortKey="Manier, Salomon" sort="Manier, Salomon" uniqKey="Manier S" first="Salomon" last="Manier">Salomon Manier</name>
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<author><name sortKey="Mohty, Mohamad" sort="Mohty, Mohamad" uniqKey="Mohty M" first="Mohamad" last="Mohty">Mohamad Mohty</name>
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<author><name sortKey="Avet Loiseau, Herve" sort="Avet Loiseau, Herve" uniqKey="Avet Loiseau H" first="Herve" last="Avet-Loiseau">Herve Avet-Loiseau</name>
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<author><name sortKey="Leleu, Xavier" sort="Leleu, Xavier" uniqKey="Leleu X" first="Xavier" last="Leleu">Xavier Leleu</name>
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<author><name sortKey="Ervin Haynes, Annette" sort="Ervin Haynes, Annette" uniqKey="Ervin Haynes A" first="Annette" last="Ervin-Haynes">Annette Ervin-Haynes</name>
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<author><name sortKey="Chen, Guang" sort="Chen, Guang" uniqKey="Chen G" first="Guang" last="Chen">Guang Chen</name>
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<author><name sortKey="Houck, Vanessa" sort="Houck, Vanessa" uniqKey="Houck V" first="Vanessa" last="Houck">Vanessa Houck</name>
<affiliation wicri:level="2"><nlm:affiliation>Celgene Corporation, Summit, NJ, United States.</nlm:affiliation>
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<wicri:regionArea>Celgene Corporation, Summit, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Benboubker, Lotfi" sort="Benboubker, Lotfi" uniqKey="Benboubker L" first="Lotfi" last="Benboubker">Lotfi Benboubker</name>
<affiliation wicri:level="1"><nlm:affiliation>CHRU Hopital Bretonneau, Tours Cedex, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHRU Hopital Bretonneau, Tours Cedex</wicri:regionArea>
<wicri:noRegion>Tours Cedex</wicri:noRegion>
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</affiliation>
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<author><name sortKey="Hulin, Cyrille" sort="Hulin, Cyrille" uniqKey="Hulin C" first="Cyrille" last="Hulin">Cyrille Hulin</name>
<affiliation wicri:level="1"><nlm:affiliation>Bordeaux Hospital University Center (CHU), France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Bordeaux Hospital University Center (CHU)</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Final analysis of survival outcomes in the randomized phase 3 FIRST trial.</title>
<author><name sortKey="Facon, Thierry" sort="Facon, Thierry" uniqKey="Facon T" first="Thierry" last="Facon">Thierry Facon</name>
<affiliation wicri:level="3"><nlm:affiliation>Service des Maladies du Sang, Hopital Claude Huriez, Lille, France; thierry.facon@chru-lille.fr.</nlm:affiliation>
<country wicri:rule="url">France</country>
<wicri:regionArea>Service des Maladies du Sang, Hopital Claude Huriez, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dimopoulos, Meletios A" sort="Dimopoulos, Meletios A" uniqKey="Dimopoulos M" first="Meletios A" last="Dimopoulos">Meletios A. Dimopoulos</name>
<affiliation wicri:level="1"><nlm:affiliation>National and Kapodistrian University of Athens School of Medicine, Greece.</nlm:affiliation>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>National and Kapodistrian University of Athens School of Medicine</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dispenzieri, Angela" sort="Dispenzieri, Angela" uniqKey="Dispenzieri A" first="Angela" last="Dispenzieri">Angela Dispenzieri</name>
<affiliation wicri:level="2"><nlm:affiliation>Mayo Clinic, Rochester, MN, United States.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mayo Clinic, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Catalano, John V" sort="Catalano, John V" uniqKey="Catalano J" first="John V" last="Catalano">John V. Catalano</name>
<affiliation wicri:level="1"><nlm:affiliation>Frankston Hospital and Monash University, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Frankston Hospital and Monash University</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Belch, Andrew" sort="Belch, Andrew" uniqKey="Belch A" first="Andrew" last="Belch">Andrew Belch</name>
<affiliation wicri:level="1"><nlm:affiliation>Cross Cancer Institute, Edmonton, Canada.</nlm:affiliation>
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<wicri:regionArea>Cross Cancer Institute, Edmonton</wicri:regionArea>
<wicri:noRegion>Edmonton</wicri:noRegion>
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</author>
<author><name sortKey="Cavo, Michele" sort="Cavo, Michele" uniqKey="Cavo M" first="Michele" last="Cavo">Michele Cavo</name>
<affiliation wicri:level="1"><nlm:affiliation>Bologna University School of Medicine, Seragnoli Institute of Hematology, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Bologna University School of Medicine, Seragnoli Institute of Hematology</wicri:regionArea>
<wicri:noRegion>Seragnoli Institute of Hematology</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pinto, Antonello" sort="Pinto, Antonello" uniqKey="Pinto A" first="Antonello" last="Pinto">Antonello Pinto</name>
<affiliation wicri:level="1"><nlm:affiliation>Head Department of Hematology and Developmental Therapeutics, National Cancer Institute, Fondazione "Pascale", Naples, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Head Department of Hematology and Developmental Therapeutics, National Cancer Institute, Fondazione "Pascale", Naples</wicri:regionArea>
<wicri:noRegion>Naples</wicri:noRegion>
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</author>
<author><name sortKey="Weisel, Katja" sort="Weisel, Katja" uniqKey="Weisel K" first="Katja" last="Weisel">Katja Weisel</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Tuebingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Tuebingen</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ludwig, Heinz" sort="Ludwig, Heinz" uniqKey="Ludwig H" first="Heinz" last="Ludwig">Heinz Ludwig</name>
<affiliation wicri:level="3"><nlm:affiliation>Wilhelminenspital, Center for Oncology, Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Wilhelminenspital, Center for Oncology, Vienna</wicri:regionArea>
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<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bahlis, Nizar J" sort="Bahlis, Nizar J" uniqKey="Bahlis N" first="Nizar J" last="Bahlis">Nizar J. Bahlis</name>
<affiliation wicri:level="4"><nlm:affiliation>University of Calgary, Southern Alberta Cancer Research Institute, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of Calgary, Southern Alberta Cancer Research Institute</wicri:regionArea>
<orgName type="university">Université de Calgary</orgName>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Banos, Anne" sort="Banos, Anne" uniqKey="Banos A" first="Anne" last="Banos">Anne Banos</name>
<affiliation wicri:level="3"><nlm:affiliation>Centre Hospitalier de la Cote Basque, Bayonne, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier de la Cote Basque, Bayonne</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bayonne</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tiab, Mourad" sort="Tiab, Mourad" uniqKey="Tiab M" first="Mourad" last="Tiab">Mourad Tiab</name>
<affiliation wicri:level="1"><nlm:affiliation>University Hospital La Roche Sur Yon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Hospital La Roche Sur Yon</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Delforge, Michel" sort="Delforge, Michel" uniqKey="Delforge M" first="Michel" last="Delforge">Michel Delforge</name>
<affiliation wicri:level="1"><nlm:affiliation>University Hospital Leuven, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>University Hospital Leuven</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cavenagh, Jamie D" sort="Cavenagh, Jamie D" uniqKey="Cavenagh J" first="Jamie D" last="Cavenagh">Jamie D. Cavenagh</name>
<affiliation wicri:level="3"><nlm:affiliation>Barts Health NHS Trust, London, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Barts Health NHS Trust, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Geraldes, Catarina" sort="Geraldes, Catarina" uniqKey="Geraldes C" first="Catarina" last="Geraldes">Catarina Geraldes</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospitais da Universidade de Coimbra, Portugal.</nlm:affiliation>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Hospitais da Universidade de Coimbra</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lee, Je Jung" sort="Lee, Je Jung" uniqKey="Lee J" first="Je-Jung" last="Lee">Je-Jung Lee</name>
<affiliation><nlm:affiliation>Chonnam National University Hwasun Hospital, Jeollanamdo, Korea, Republic of.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Chen, Christine" sort="Chen, Christine" uniqKey="Chen C" first="Christine" last="Chen">Christine Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Princess Margaret Hospital, Toronto, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Princess Margaret Hospital, Toronto</wicri:regionArea>
<wicri:noRegion>Toronto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oriol, Albert" sort="Oriol, Albert" uniqKey="Oriol A" first="Albert" last="Oriol">Albert Oriol</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut Catala d'Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Badalona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Institut Catala d'Oncologia and Institut Josep Carreras, Hospital Germans Trias i Pujol, Badalona</wicri:regionArea>
<wicri:noRegion>Badalona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De La Rubia, Javier" sort="De La Rubia, Javier" uniqKey="De La Rubia J" first="Javier" last="De La Rubia">Javier De La Rubia</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital Dr. Peset, Valencia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital Dr. Peset, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="White, Darell" sort="White, Darell" uniqKey="White D" first="Darell" last="White">Darell White</name>
<affiliation wicri:level="1"><nlm:affiliation>Queen Elizabeth II Health Sciences Centre, Halifax, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Queen Elizabeth II Health Sciences Centre, Halifax</wicri:regionArea>
<wicri:noRegion>Halifax</wicri:noRegion>
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</author>
<author><name sortKey="Binder, Daniel" sort="Binder, Daniel" uniqKey="Binder D" first="Daniel" last="Binder">Daniel Binder</name>
<affiliation wicri:level="1"><nlm:affiliation>Kantonsspital Winterthur, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Kantonsspital Winterthur</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lu, Jin" sort="Lu, Jin" uniqKey="Lu J" first="Jin" last="Lu">Jin Lu</name>
<affiliation wicri:level="3"><nlm:affiliation>Peking University People's Hospital, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Peking University People's Hospital, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Anderson, Kenneth C" sort="Anderson, Kenneth C" uniqKey="Anderson K" first="Kenneth C" last="Anderson">Kenneth C. Anderson</name>
<affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA, United States.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dana-Farber Cancer Institute, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moreau, Philippe" sort="Moreau, Philippe" uniqKey="Moreau P" first="Philippe" last="Moreau">Philippe Moreau</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Nantes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>University of Nantes</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Attal, Michel" sort="Attal, Michel" uniqKey="Attal M" first="Michel" last="Attal">Michel Attal</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut Universitaire du Cancer, Toulouse-Oncopole, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Universitaire du Cancer, Toulouse-Oncopole</wicri:regionArea>
<wicri:noRegion>Toulouse-Oncopole</wicri:noRegion>
<wicri:noRegion>Toulouse-Oncopole</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Perrot, Aurore" sort="Perrot, Aurore" uniqKey="Perrot A" first="Aurore" last="Perrot">Aurore Perrot</name>
<affiliation wicri:level="4"><nlm:affiliation>CHU de Nancy, Universite de Lorraine, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU de Nancy, Universite de Lorraine</wicri:regionArea>
<wicri:noRegion>Universite de Lorraine</wicri:noRegion>
<placeName><settlement type="city">Nancy</settlement>
<settlement type="city">Metz</settlement>
<region type="region" nuts="2">Grand Est</region>
<region type="old region" nuts="2">Lorraine (région)</region>
</placeName>
<orgName type="university">Université de Lorraine</orgName>
</affiliation>
</author>
<author><name sortKey="Arnulf, Bertrand" sort="Arnulf, Bertrand" uniqKey="Arnulf B" first="Bertrand" last="Arnulf">Bertrand Arnulf</name>
<affiliation wicri:level="3"><nlm:affiliation>Hopital Saint Louis, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hopital Saint Louis, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Qiu, Lugui" sort="Qiu, Lugui" uniqKey="Qiu L" first="Lugui" last="Qiu">Lugui Qiu</name>
<affiliation wicri:level="3"><nlm:affiliation>Blood Disease Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Blood Disease Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin</wicri:regionArea>
<placeName><settlement type="city">Tianjin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Roussel, Murielle" sort="Roussel, Murielle" uniqKey="Roussel M" first="Murielle" last="Roussel">Murielle Roussel</name>
<affiliation wicri:level="3"><nlm:affiliation>CHU Purpan/IUCT Oncopole, Toulouse, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU Purpan/IUCT Oncopole, Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boyle, Eileen" sort="Boyle, Eileen" uniqKey="Boyle E" first="Eileen" last="Boyle">Eileen Boyle</name>
<affiliation wicri:level="3"><nlm:affiliation>Service des Maladies du Sang, Hopital Claude Huriez, Lille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service des Maladies du Sang, Hopital Claude Huriez, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Manier, Salomon" sort="Manier, Salomon" uniqKey="Manier S" first="Salomon" last="Manier">Salomon Manier</name>
<affiliation wicri:level="3"><nlm:affiliation>Service des Maladies du Sang, Hopital Claude Huriez, Lille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service des Maladies du Sang, Hopital Claude Huriez, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mohty, Mohamad" sort="Mohty, Mohamad" uniqKey="Mohty M" first="Mohamad" last="Mohty">Mohamad Mohty</name>
<affiliation wicri:level="3"><nlm:affiliation>Hopital Saint-Antoine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hopital Saint-Antoine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Avet Loiseau, Herve" sort="Avet Loiseau, Herve" uniqKey="Avet Loiseau H" first="Herve" last="Avet-Loiseau">Herve Avet-Loiseau</name>
<affiliation wicri:level="3"><nlm:affiliation>Unite de Genomique du Myelome, CHU Rangueil, Toulouse, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unite de Genomique du Myelome, CHU Rangueil, Toulouse</wicri:regionArea>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leleu, Xavier" sort="Leleu, Xavier" uniqKey="Leleu X" first="Xavier" last="Leleu">Xavier Leleu</name>
<affiliation wicri:level="3"><nlm:affiliation>Hopital de la Miletrie, CHU INSERM, Poitiers, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hopital de la Miletrie, CHU INSERM, Poitiers</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Poitou-Charentes</region>
<settlement type="city">Poitiers</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ervin Haynes, Annette" sort="Ervin Haynes, Annette" uniqKey="Ervin Haynes A" first="Annette" last="Ervin-Haynes">Annette Ervin-Haynes</name>
<affiliation wicri:level="2"><nlm:affiliation>Celgene Corporation, Summit, NJ, United States.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Celgene Corporation, Summit, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Guang" sort="Chen, Guang" uniqKey="Chen G" first="Guang" last="Chen">Guang Chen</name>
<affiliation wicri:level="2"><nlm:affiliation>Celgene Corporation, Summit, NJ, United States.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Celgene Corporation, Summit, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Houck, Vanessa" sort="Houck, Vanessa" uniqKey="Houck V" first="Vanessa" last="Houck">Vanessa Houck</name>
<affiliation wicri:level="2"><nlm:affiliation>Celgene Corporation, Summit, NJ, United States.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Celgene Corporation, Summit, NJ</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Benboubker, Lotfi" sort="Benboubker, Lotfi" uniqKey="Benboubker L" first="Lotfi" last="Benboubker">Lotfi Benboubker</name>
<affiliation wicri:level="1"><nlm:affiliation>CHRU Hopital Bretonneau, Tours Cedex, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHRU Hopital Bretonneau, Tours Cedex</wicri:regionArea>
<wicri:noRegion>Tours Cedex</wicri:noRegion>
<wicri:noRegion>Tours Cedex</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hulin, Cyrille" sort="Hulin, Cyrille" uniqKey="Hulin C" first="Cyrille" last="Hulin">Cyrille Hulin</name>
<affiliation wicri:level="1"><nlm:affiliation>Bordeaux Hospital University Center (CHU), France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Bordeaux Hospital University Center (CHU)</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Blood</title>
<idno type="eISSN">1528-0020</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en">This FIRST trial final analysis examined survival outcomes in patients with transplant-ineligible newly diagnosed multiple myeloma (NDMM) treated with lenalidomide and low-dose dexamethasone until disease progression (Rd continuous), Rd for 72 weeks (18 cycles; Rd18), or melphalan, prednisone, and thalidomide (MPT; 72 weeks). The primary endpoint was progression-free survival (PFS; primary comparison: Rd continuous vs MPT). Overall survival (OS) was a key secondary endpoint (final analysis prespecified ≥ 60 months' follow-up). Patients were randomized to Rd continuous (n = 535), Rd18 (n = 541), or MPT (n = 547). At a median follow-up of 67 months, PFS was significantly longer with Rd continuous vs MPT (HR, 0.69; 96% CI, 0.59-0.79; P < .00001) and was similarly extended vs Rd18. Median OS was 10 months longer with Rd continuous vs MPT (59.1 vs 49.1 months; HR, 0.78; 95% CI, 0.63-0.95; P = .0144), and similar with Rd18 (62.3 months). In patients achieving complete or very good partial responses, Rd continuous had a ≈ 30-month-longer median time to next treatment vs Rd18 (69.5 vs 39.9 months). Over half of all patients who received second-line treatment were given a bortezomib-based therapy. Second-line outcomes were improved in patients receiving bortezomib after Rd continuous and Rd18 vs after MPT. No new safety concerns, including risk for secondary malignancies, were observed. Treatment with Rd continuous significantly improved survival outcomes vs MPT, supporting Rd continuous as a standard of care for patients with transplant-ineligible NDMM. Study registration is at Clinicaltrials.gov (NCT00689936) and EudraCT (2007-004823-39).</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Autriche</li>
<li>Belgique</li>
<li>Canada</li>
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<li>France</li>
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<li>Italie</li>
<li>Portugal</li>
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</list>
<tree><noCountry><name sortKey="Lee, Je Jung" sort="Lee, Je Jung" uniqKey="Lee J" first="Je-Jung" last="Lee">Je-Jung Lee</name>
</noCountry>
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Serveur d'exploration sur les relations entre la France et l'Australie

Final analysis of survival outcomes in the randomized phase 3 FIRST trial.

Final analysis of survival outcomes in the randomized phase 3 FIRST trial.

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Abstract

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	Serveur d'exploration sur les relations entre la France et l'Australie
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